The Maryland women upset Virginia last month on the road but were unable to repeat the feat at home Monday night, losing, 82-68.
The Terps (16-8, 3-6 Atlantic Coast Conference) suffered their fifth overall loss in their past seven games and their fourth in a row at Comcast Center after 48 consecutive home victories. The three previous home losses were by a total of five points.
Monica Wright scored a game-high 34 points for the Cavaliers (17-6, 6-3 ACC), including 22 in the second half.
Maryland freshman Tianna Hawkins earned her fourth career double double with 18 points and 10 rebounds, leading the squad in both categories.
The Terps led 35-32 at halftime after taking the lead with a 17-6 run sparked by a jumper from Lori Bjork with 3:42 on the clock.
Virginia went ahead in the second half with 16:13 remaining and never trailed again.
Maryland got 11 points and four rebounds off the bench from freshman Jackie Nared.