Sources familiar with the situation said Anderson had not been in his College Park office since the end of September.
Anderson and university president Wallace Loh have been at odds for a couple of years, one source said.
Their issues escalated in recent months when Anderson, a San Francisco native, spoke with the University of California about the vacant athletic director job without telling Loh, who learned of Anderson's discussions with officials in Berkeley.
One source said Anderson was upset when the Cole Field House renovation project was expanded and the costs rose from $155 million to $196 million, with the once-financially-strapped athletic department being told it had to contribute as much as $18 million.
Anderson has been a polarizing figure for much of his tenure, starting with his firing of popular football coach Ralph Friedgen, a Maryland alumnus, after he led the Terps to a 9-4 record in 2010 and was named Atlantic Coast Conference Coach of the Year.
The Terps' nonrevenue sports have also been successful. Maryland's men's and women's lacrosse teams won NCAA titles this past spring. The soccer, field hockey and baseball programs have been consistent winners.
Neither Anderson nor Loh could be reached for comment.
Asked after Saturday's 37-21 loss to Northwestern, second-year football coach DJ Durkin was asked whether he was aware of the turmoil surrounding Anderson and whether it had an effect on his team's play.
"It didn't have an effect on our team," said Durkin, who was brought in by Anderson after serving as defensive coordinator at Michigan. "I don't know what got out. … I don't think the players even were aware of it."