The mistake-prone Jeremy Guthrie from last season had been noticeably absent through four starts, but he reappeared Wednesday night in time to wipe out the Orioles' hopes of building on an all-too modest winning streak.
Guthrie was hammered for seven runs over 4 2/3 innings, while his counterpart and former Cleveland Indians teammate CC Sabathia scattered 11 hits over 7 2/3 innings in the New York Yankees' 8-3 victory in front of an announced 17,248 at Camden Yards.
The loss, pretty much a formality after the Yankees built a 5-0 lead off Guthrie by the top of the second inning, dropped the Orioles to 4-17 and ended their brief foray with winning at two games.
Nick Markakis had three hits, including his first home run, and Miguel Tejada, Garrett Atkins and Cesar Izturis also had multi-hit games for the Orioles, who went just 2-for-12 with runners in scoring position.
The Yankees, meanwhile, totaled 15 hits and had runs in five of the first six innings.
Guthrie, who went at least six innings and allowed three earned runs or less in his first four outings, didn't make it through the fifth as he surrendered six hits, a walk and hit a batter through 4 2/3 in falling to 0-3. Of the eight base runners he allowed, seven of them scored, including one who was inherited by long reliever Mark Hendrickson, who was also knocked around for one run and five hits in one inning.
What made Guthrie successful in his first four outings was precise fastball command and keeping all of his pitches down in the strike zone. But he never appeared comfortable doing either Wednesday night, and he also didn't get much help defensively, at least early.
In his first four starts, Guthrie hadn't allowed a first-inning run after he surrendered 29 runs in first innings last season. But on Wednesday night, he was behind 1-0 before the Yankees' third hitter came to the plate.
Derek Jeter led off the game with a double down the right-field line on a ball that first baseman Atkins got a slow break on. Nick Johnson followed with a single that left fielder Lou Montanez's misplayed, allowing Jeter to score and Johnson to get to second. Alex Rodriguez then stretched New York's lead to 2-0 with a sacrifice fly.
Guthrie, who irritated Yankees manager Joe Girardi in spring training when he hit both Mark Teixeira and Francisco Cervelli in the first inning of a game, hit Jorge Posada on his first pitch of the second. Posada limped to first and scored later in the inning, but he didn't come out for the bottom of the frame and was later diagnosed with a right knee bruise. The Yankees also did not retaliate.
Curtis Granderson followed the hit batsman with a single, and then Nick Swisher, who entered the game with nine hits off Guthrie in 19 at-bats, scored them both with a triple off the center-field wall. The ball bounced over the head of Orioles center fielder Adam Jones, who then threw wildly toward the infield as Swisher slid into third.
Jeter made it 5-0 with a sacrifice fly, and then Robinson Cano tacked on another run with a solo homer to right in the third inning. It was the third homer allowed this season by Guthrie after he allowed an American League-leading 35 last season.
The Orioles had two runners on in the first inning, but Sabathia struck out Matt Wieters for the first of three times Wednesday night.
Trailing 6-0, the Orioles got their first run in the third inning on Miguel Tejada's RBI groundout, but they squandered numerous chances to get back in the game. Sabathia clearly didn't have his best stuff, but what he did have was plenty good enough.