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Worst loss: Twins 4, Orioles 3 (12) on Aug. 23

The Orioles suffered far more lopsided defeats, including a 15-2 rout to start this series against the Minnesota Twins, and were no-hit in 2015. But this was perhaps their most meaningful loss of the season. Kevin Gausman was dominant and the Orioles were on the verge of avoiding a four-game sweep, leading 3-2 in the ninth. But Trevor Plouffe's two-out single off Zach Britton tied the game. Adam Jones struck out swinging with the potential winning run in scoring position in the 11th (pictured). Two errors in the top of the 12th brought home the eventual winner for the Twins. It might not seem so bad, but it capped a four-game sweep and the Orioles' spiral was on. That sparked a stretch of 15 losses in 18 games, and the Orioles never recovered. 

Mitchell Layton / Getty Images
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