The 22-year-old right-hander, who recalled from Double-A last week, was pulled after four innings, trailing 7-3 to the Washington Nationals.
He gave up seven runs on eight hits, including three homers. Combined with his debut on Thursday in Toronto, in which he gave up four earned runs in five innings, Gausman's ERA sits at 11.00.
On Tuesday, he permitted a three-run homer to Adam LaRoche in the first inning. He then retired seven of eight before walking LaRoche to start the fourth. Tyler Moore followed with a one-out, two-run homer and then Roger Bernadina hit a solo shot for back-to-back home runs.
Six of the seven runs he allowed came via the homer. The last run scored on a double by Denard Span. He was throwing his fastball in the mid-to-high 90s, but was elevating it continually.
Now the question is whether Gausman makes his next start against Detroit on Sunday or if he gets sent back to the minors.
Meanwhile, Washington's Nate Karns, who was making his big league debut, allowed three earned runs on five hits (two homers), and two walks. He struck out three.