On Wednesday, as Margevicius was continuing the excellent premature start to his major league career, allowing one run in six innings, Machado was fielding ground balls and making plays and hitting a solo home run off the top of Oracle Park's right field wall that was the deciding run in a 3-1 victory over the Giants.
With that, the Padres clinched their third series win in the four they've played in 2019. They are 4-2 on a road trip that continues Thursday in Phoenix with the first of four games against the Diamondbacks.
Their 8-5 start has been bettered once (2009) and matched once (2015) in the franchise's past 20 years.
Machado made at least three plays in the field that Margevicius, who got his first major league victory, said "pretty much saved the game at different points."
That included a barehanded grab of a slow roller and throw across the diamond for an out in the third inning and a catch for the final out on a skied pop-up that would have been routine had the sun not proven a challenge all day.
"We're all screaming in the dugout (that) no one catches that last ball but Manny," Green said. "We trust a lot of guys on the field, but we like him using his hands the most."
In between those two plays, Machado contributed to saving a run by fielding a slow chopper that was slicing away from him and throwing home as his body drifted toward shortstop. Catcher Francisco Mejia grabbed the high and hard throw, came down and tagged out Erik Kratz.
"I was just trying to turn two," Machado said. "But how the ground ball was hit, I think at that point we weren't going to get (the runner) going to first. So I was trying to get one out."
Machado is nonchalant about almost all he does on the field, because he has been doing what he does for so long. It was clear, however, that his throw surprised Kratz, who didn't even slide, thinking Machado would cede the run and get an out at first base.
Asked how many third baseman would have been able to make that play, second baseman Ian Kinsler said, "Not many."
Margevicius struck out Steven Duggar to end the fifth.
Machado, up second in the sixth, launched a first-pitch fastball for his third homer of the season, breaking a 1-1 tie. His high fly ball barely cleared the two-story brick facade and bounced off the green metal roof, giving him just the 22nd home run by a right-handed hitter to right field in the 19 years Oracle Park has been the Giants' home.
"He made one mistake all day," Machado said of Giants starter Dereck Rodriguez. "I was able to take advantage."
The only other run Rodriguez (1-2) allowed in his seven innings came in the second, when Luis Urias walked, went to second base on Margevicius' sacrifice bunt and scored on Manuel Margot's single.
The Padres added a run in the ninth when Hunter Renfroe tripled and Wil Myers drove him home with a single.