Columbus also got goals from Cam Atkinson, Zach Werenski, Riley Nash and Artemi Panarin. The Blue Jackets started the postseason last season by winning the first two games of the first-round series with eventual Stanley Cup Washington, which won the next four games.
Mikhail Sergachev had a goal and Andrei Vasilevskiy stopped 22 shots for the Lightning, who lost two games in a row just twice in the regular season. Tampa Bay matched the 1995-96 Detroit Red Wings for the most wins in a regular season with 62.
Lightning right wing Nikita Kucherov, who led the NHL with 128 points, was held off the scoresheet for the second consecutive game and picked up tripping, boarding and 10-minute misconduct penalties late in the third period.
The Blue Jackets rallied from a three-goal, first-period deficit to beat Tampa Bay 4-3 in Game 1 on Wednesday night as Seth Jones scored the go-ahead goal on the power play to cap Columbus' three-goal third period.
N.Y. Islanders 3, Pittsburgh 1
Anthony Beauvillier also scored and Robin Lehner stopped 32 shots to help New York open a postseason series with two wins for the first time since sweeping Edmonton in the 1983 Stanley Cup Final for the Islanders' fourth straight championship.
Mathew Barzal had two assists in a chippy, physical game that featured a lot of hard hits and some skirmishes, especially in the first two periods — and also after the final buzzer.
Erik Gudbranson scored and Matt Murray finished with 31 saves for the Penguins, who have lost the first two games of a postseason series for the first time since the 2013 Eastern Conference finals against Boston.
Game 3 is Sunday at Pittsburgh.
St. Louis 4, Winnipeg 3
O'Reilly gave the Blues the 4-3 lead at 3:46 of the third when he used Jets defenseman Ben Chiarot as a screen to beat Hellebuyck on the blocker side. It was his first playoff goal since 2014, when he was with Colorado.
Vegas 5, San Jose 3
Mark Stone scored the tiebreaking goal on a power play created by a penalty that negated an apparent San Jose goal and the Vegas Golden Knights responded after blowing a three-goal lead in the first period to beat the Sharks 5-3 on Friday night to tie their playoff series at one game apiece.
The teams packed an entire game into the opening minutes with the Golden Knights scoring three goals in the first 6:11 and the Sharks rallying for three more in the final 3:01 to become the first team in NHL history to tie a playoff game in the first period after falling behind 3-0.
The craziness continued at the start of the second period when the Sharks briefly celebrated an apparent goal in the opening minute by Brent Burns. That quickly turned to frustration when the officials waved off the goal because Logan Couture interfered with Marc-Andre Fleury, giving the Golden Knights the power play.
Stone converted from the slot after a scramble for his third goal of the series and Vegas held on from there, thanks in part to 34 saves from Fleury.
Cody Eakin, Colin Miller and Max Pacioretty all scored in the first period to stake the Golden Knights to the big lead after losing the opener 5-2. William Karlsson added a short-handed goal in the third to ice it.
Game 3 will be Sunday night in Las Vegas.