Jack Near scored Notre Dame's final goal with 1:14 left in the third quarter for a 10-7 lead. Denver went on a 4-0 run over the fourth quarter and overtime.
Matt Kavanagh had four goals for the Fighting Irish.
No. 1 Syracuse 14, St. John's 6: Randy Staats had five goals to power the Orange (5-0) past the Red Storm (1-5) at the Cobb County Classic in Kennesaw, Ga.
"Give some credit to St. John's. I thought they played really hard in the first and second quarter," Syracuse coach John Desko said. The Orange "were a little bit asleep. We finally woke up at the end of the second quarter."
Syracuse trailed by two goals at halftime before outscoring St. John's 12-2 in the second half.
Joe Lang had four goals and Bryan Moore (Gilman) made 12 saves for Harvard.
Boston University 18, No. 18 Colgate 11: The Terriers (4-2, 1-1 Patriot) used a 6-2 run in the fourth quarter to upset the host Raiders (4-1, 2-1).
Ryan Hilburn had a game-high four goals for Boston University.
No. 19 Villanova 17, No. 20 Penn 11: Jack Curran scored four goals and Sean Cerrone had two goals and five assists as the Wildcats (4-1) withstood a late rally by the host Quakers (3-3) to win their fourth straight game.
No. 2 North Carolina 10, No. 8 Virginia 7: Molly Hendrick had three goals and Sammy Jo Tracy scored two to power the host Tar Heels (6-1, 1-0 Atlantic Coast Conference) past the Cavaliers (3-3, 0-2).
Hendrick started a 3-0 run early in the first half to break a 1-all tie. Kasey Behr led Virginia with three goals.
No. 4 Boston College 15, No. 15 Notre Dame 6: Covie Stanwick (Notre Dame Prep) had seven goals and an assist to power the host Eagles (6-0, 2-0 ACC) past the Fighting Irish (3-3, 0-2).
Notre Dame tied the score at 3 with 11:19 left in the first half. Boston College answered with a 9-0 run that spanned both halves. Stanwick scored five goals during the run.
No. 7 Northwestern 14, Colorado 8: Led by freshmen Corinne Wessels (one goal, five assists) and Selena Lasota (five goals), the host Wildcats (4-2) outscored the Buffaloes (2-2) 10-4 in the second half, including a 6-0 run after falling behind 6-5.
Northwestern had lost two of its previous three games.
No. 9 Princeton 8, Dartmouth 5: Stephanie Paloscio had two goals and two assists to lead the Tigers (4-0, 1-0 Ivy League) past the host Big Green (0-4, 0-1).
Princeton broke a 3-all halftime score with a 5-2 run in the second half.
No. 13 Penn 9, Brown 7: Tory Bensen and Nina Corcoran had three goals each to lead the Quakers (4-0, 1-0 Ivy) past the host Bears (3-1, 0-1).
No. 14 Louisville 18, William & Mary 5: Cortnee Daley scored five goals and Kelli Gerding (North Harford) added four to lead the Cardinals (5-0) past the host Tribe (0-4).