Even after fighting back to tie the game in the fourth quarter, host No. 2 seed Syracuse could not break through against Bryant, which never trailed en route to a 10-9 upset on Sunday night.
Led by attacker Tucker James' four goals and two assists, the Bulldogs (16-4) surprised the Orange (11-5) in the first round of the NCAA Division I tournament. Bryant will face Maryland in a quarterfinal Saturday at Hofstra.
The Orange outshot the Bulldogs 38-27, but Bryant goalkeeper Gunnar Waldt made 13 saves and his team won 14 of 23 faceoffs.
No. 1 Duke 20, Air Force 9: The host Blue Devils outscored the Falcons 7-1 in the second quarter of their first-round victory.
Midfielder Myles Jones, who scored twice in the first 10 minutes to help Duke (14-3) to a 5-2 first-period lead, finished with a game-high eight points on three goals and five assists. The Blue Devils outshot Air Force (11-6) 52-35 and outscored the Falcons in each quarter. Duke advances to play Johns Hopkins on Sunday at Delaware.
Drexel 16, No. 4 Penn 11: The Dragons, playing in their first NCAA tournament, surged in the second quarter to upset the host Quakers.
Penn (11-4) scored the first two goals and led 4-3 after the first quarter. But the Dragons (13-4) took a 7-6 edge just before halftime, then scored the next four goals. Drexel will play No. 5 seed Denver on Sunday at Delaware.
No. 2 Syracuse 13, Stony Brook 6: The Orange (19-2) tied its record for most wins in a season as attacker Alyssa Murray's four goals paced Syracuse in a rout of the visiting Seawolves (17-4) in the second round.
Murray scored the Orange's first four goals in the opening 10 minutes, and Syracuse jumped out to a 10-2 halftime lead. The Orange will play No. 7 seed Boston College in a quarterfinal Saturday.
No. 3 seed North Carolina 10, Georgetown 8: The Tar Heels distanced themselves from the visiting Hoyas with a late four-goal rally, and North Carolina attacker Abbey Friend scored four times for a program-high 195 career goals.
North Carolina (15-4) outshot the Hoyas (11-9) 14-9 after the break, and goalkeeper Megan Ward (St. Mary's) made eight saves. The Tar Heels will play Virginia on Saturday.
No. 4 Florida 19, Denver 9: The Gators went on five- and eight-goal runs in the second half to put the game out of reach for the visiting Pioneers (19-2).
Attacker Devon Schneider and midfielders Mollie Stevens and Shannon Gilroy combined for 12 goals for Florida (18-2), which will play Northwestern on Saturday.
No. 5 Northwestern 11, Louisville 8: Attacker Kara Mupo scored four goals to lead the host Wildcats past midfielder Cortnee Daley (four goals) and the Cardinals.
Northwestern (13-6) led 4-3 at halftime. Louisville (16-4) went ahead, 5-4, with 26:23 left, but the Wildcats responded with four straight goals. Northwestern will play Florida on Saturday.
No. 6 Virginia 13, Princeton 11: The host Cavaliers (11-8) scored the first four goals, but the Tigers (12-7) came back to within 5-4 and matched Virginia's four-goal second-half run with one of their own to keep the game close.
The Cavaliers will play North Carolina on Saturday.
Duke 10, No. 8 Notre Dame 8: Midfielder Maddy Morrisey paced the Blue Devils (11-7) with a career-high six points on four goals and two assists in Duke's second-round victory over the host Fighting Irish (10-9).
Latest College Lacrosse
The Blue Devils jumped ahead with a five-goal run that spanned halftime. The Blue Devils will face No. 1 Maryland on Saturday.