Midfielder Deemer Class (Loyola High) scored six times, and three other Blue Devils had four or more goals as No. 4 Duke rushed past the visiting No. 9 Orange, 21-7.
After Syracuse (4-3, 0-3 Atlantic Coast Conference) went up, 2-1, in the first quarter, the Blue Devils (8-2, 2-1) started a 10-0 run that included hat tricks by Class and midfielder Myles Jones, who finished with five goals.
The Orange, led by attackman Randy Staats' two goals, didn't score again until 7:16 remained in the half, and Duke answered each Syracuse goal with one or more of its own.
No. 3 Syracuse 11, No. 8 Northwestern 7: After a tight first half, host Syracuse (9-1) went on a four-goal run early in the second half and held off the Wildcats (4-3) for the win.
Northwestern attacker Kara Mupo led all players with three goals. Attacker Kayla Treanor and midfielders Amy Cross and Katie Webster each had two goals for the Orange.
No. 6 Notre Dame 17, Villanova 8: The Fighting Irish led 9-4 at halftime and ran away from the host Wildcats with a six-goal spurt in the second half.
Attacker Kiera McMullan and midfielder Brie Custis each had a game-high three goals for Notre Dame (8-3), and midfielder Casey Pearsall had an Irish-record-tying nine draw controls.
Villanova (4-4) midfielders Hannah Goforth and Becca Hetrick both scored twice.
No. 13 Penn State 20, Michigan 7: Eleven Nittany Lions scored, and midfielder Kelly Lechner had her 100th career point as Penn State (6-3, 2-0 American Lacrosse Conference) beat the visiting Wolverines (0-8, 0-4).
The Nittany Lions outshot Michigan 38-14 and led 15-5 at halftime. Attackers Jess Loizeaux and Maggie McCormick (Liberty) and midfielders Madison Cyr and Tatum Coffey had hat tricks for Penn State. Michigan goalkeeper Allison Silber (McDonogh) made 14 saves.