Steph Lazo (St. Mary's) scored in overtime to lift Penn State (13-6) over host and No. 2 seed Florida (18-2) in a second-round game.
Katie O'Donnell had a game-high five goals and Madison Cyr (Winters Mill) had six points on four goals and two assists and Lazo punctuated her four-point afternoon with her only goal of the game for the Nittany Lions.
Florida took a 13-12 lead with 18:11 left in the second half before the Nittany Lions' Jenna Mosketti (Fallston) tied the game with 11:21 to go as the Gators stalled the ball in the final 6:30 for the last shot. Mosketti finished with a game-high six draw controls.
Penn State will host No. 7 seed Penn in the quarterfinals on Saturday at noon.
No. 3 seed North Carolina 15, Duke 10: The Tar Heels (17-2) went on a 5-1 run to start the second half and beat the visiting Blue Devils (11-9) in a second-round game. The Tar Heels will host No. 6 seed Notre Dame on Saturday at noon.
No. 4 seed Syracuse 7, Stony Brook 6: The Orange (18-5) scored four straight goals in the second half to defeat the Seawolves (17-4) in a second-round game at Boston College. Syracuse advances to the quarterfinals where they will host No. 5 seed Southern California on Saturday at 3 p.m.
Stony Brook led 4-3 at halftime and went up by two with 26:43 remaining before the Orange rallied.
No. 5 seed Southern California 14, Stanford 8: Michaela Michael had a game-high five points on three goals and two assists to power the host Trojans (20-0) over the Cardinal (15-5).
No. 6 seed Notre Dame 15, Northwestern 3: The Fighting Irish (14-6) ended the game on a 9-0 run to cruise past the visiting Wildcats (11-10) in a second-round game.
Cortney Fortunato and Grace Muller each scored four goals for the Irish.
No. 7 seed Penn 12, Towson 4: Iris Williamson had four goals to lift the host Quakers (15-4) over the Tigers in a second-round game. Towson (16-4) tied the 2012 team for the program's best season record.
Caroline Cummings scored the first of her three goals for Penn with 5:12 to go in the first half, which started an 8-0 run that bridged the first and second halves that gave the Quakers a 12-2 lead with 7:58 to play.
UMass 7, No. 8 seed Cornell 6: Erika Eipp and Eileen McDonald each had two goals and two assists to lead the Minutewomen (20-1) over the Big Red (14-5).
UMass will face No. 1 seed Maryland in the quarterfinals Sunday at noon.
Navy 13, No. 4 seed Yale 10: When it was over, all the Navy players threw their sticks into the air and raced to one corner of the field to mob goalkeeper John Connors.
It was the only logical response, considering the way Connors took over in the second half and spearheaded a stunning upset of fourth-seeded Yale in the first round of the NCAA men's lacrosse tournament.
Connors made eight of his 12 saves in the second half to anchor a strong defensive effort that lifted Navy to a 13-10 victory over host Yale before a an announced 3,526 at Reese Stadium in New Haven, Conn.
"Connors was awesome. He was big when they needed him to be big," Yale coach Andy Shay said. "I think he had a good look at a lot of those shots, but he was awesome today."
Connors has been a three-year starter for the Midshipmen, but has rarely had the type of difference-making performance he did on Sunday. The left-handed senior made a series of difficult stops that stole goals from the Bulldogs.
"I'd say he stole one. Some of those other ones, those are routine," Navy coach Rick Sowell said, somewhat in jest, during the postgame news conference with Connors at his side.
Connors was asked if it was the best game of his career.
"Maybe the best half. I'm not really happy with how I played in the first half. I gave up some goals on shots I should have stopped," Connors said. "Whenever they scored a goal, Chris Fennell, Jules Godino and Hiram Carter came in and said it's going to come down to whichever defense makes some stops. My defense instilled me with a lot of confidence."
Sophomore midfielder Casey Rees scored four goals as Navy won an NCAA tournament game for the first time since 2008. Sophomore attackman Jack Ray totaled three goals and an assist while senior attackman Patrick Keena contributed two goals and four assists.
Second midfielder Colin Flounlacker provided an unexpected lift with a goal and an assist for Navy (11-4), which advances to face fifth-seeded Brown (15-2) in next Saturday's quarterfinals in Providence, R.I. at 2:30 p.m.
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No. 8 seed Syracuse 11, Albany 9: The host Orange (12-4) outscored the Great Danes (12-4) 9-3 in the second half to advance to the quarterfinals against No. 1 seed Maryland.