The first six possessions of the second half ended in two safeties, two fumbles, a blocked field goal and an interception. Morgan State took a 14-7, its first of the season, lead after its two safeties but South Carolina State tied it on Quan Caldwell's 29-yard catch with 4:41 left in the third quarter.
S.C. State opened the fourth with 21 points in less than three minutes.
Two plays after Morgan State's fourth turnover, on a fumbled punt return, Samuel ran for a 15-yard touchdown to take a 21-14 lead. Darius Leonard intercepted a pass on Morgan State's next possession and ran it back 12 yards to extend the Bulldogs' lead and Samuel capped the scoring with an 89-yard TD run.
Dewann Ford was 10-of-25 passing for 141 yards and one touchdown for S.C. State (2-3, 1-2 Mid-Eastern Athletic Conference). Samuel opened the scoring on the Bulldogs' first possession with a 44-yard touchdown run.
Elijah Staley completed 15 of 37 passes for 154 yards and three interceptions for Morgan State (0-5, 0-2).
Herb Walker Jr. rushed for 68 yards on 23 carries and DeAndre Harris added 13 rushing yards on two attempts for Morgan State.
The game was tied at 14 entering the fourth quarter.