Cameron Krutwig led Loyola with 19 points Wednesday, but the Ramblers fell 75-69 to Ball State at the Gentile Center.
Marques Townes had 14 points, 10 rebounds and six assists for the Ramblers (5-4), who have lost three of their last four games.
Loyola used a 12-4 surge for a 68-67 advantage with 2:48 remaining. The Cardinals answered with Trey Moses blocking Townes' driving shot in the paint. Tahjai Teague grabbed the board, ran the court and finished with a step-back jumper in front on the net, drawing a foul. Teague converted the 3-point play, added another layup and the Cardinals led 72-68 with 1:19 left.
K.J. Walton scored 22 points to lead the Cardinals to their fifth consecutive win.
Walton made 11 of 14 field goals. Teague added 14 points, and Tayler Persons and Zach Gunn chipped in 12 apiece for the Cardinals (6-3), who shot 57 percent (28 of 49) from the floor.