Rashun Davis made a 3-pointer with 1.5 seconds left in the second overtime and finished with a career-high 28 points, and Radford upset host Georgetown, 82-80, on Saturday in the season opener.
Davis' game-winner came after he missed a pair of free throws with 39 seconds left. Georgetown's L.J. Peak missed a 3-pointer at 14 seconds.
Cameron Jones, who made back-to-back 3-pointers down the stretch, added 20 points for the Highlanders.
Georgetown, which will play at No. 3 Maryland on Tuesday night, forced the first overtime when Isaac Copeland hit a 3-pointer with 36 seconds left and Peak followed with a steal and a layup but missed the free throw after he was fouled.
The Hoyas took a three-point lead early in the first overtime, but Radford made layups on three consecutive possessions to go up by three. D'Vauntes Smith-Rivera made one of two free throws and a layup after a turnover to tie the game at 71.
Bradley Hayes had 19 points and 12 rebounds for Georgetown.
La Salle 78, Towson 76: Jordan Price scored 27 points, Johnnie Shuler hit the game-winner and the host Explorers held off the Tigers in a season opener.
Shuler scored 15 points and broke a 73-73 tie with a layup, then made three free throws in the final 40 seconds to seal the win.
Cleon Roberts and Yevgen Sakhniuk each scored 11 for La Salle, which led 45-39 at halftime.
Towson rallied to within a point three times in the second half before taking a 71-70 lead after Mike Morsell scored two free throws and a layup with 4:22 left. The game was tied at 73 for nearly 21/2 minutes before Shuler's layup and free throws.
Byron Hawkins' 3-pointer with a second left wasn't enough for the Tigers, who got 28 points from William Adala Moto, a Wake Forest transfer who sat out last season because of NCAA transfer rules.
Morsell and Hawkins each scored 13. Walter Foster had 12 rebounds.
Rider 78, Towson 72: The visiting Tigers tied the school record for 3-pointers in a game with 12 but lost the season opener for both schools.
Dominique Johnson made seven 3-pointers and finished with 22 points for Towson.
Daijha Thomas led the Tigers in rebounds with 10.
Towson led 36-35 lead at the half behind 12 points from Raven Bankston.
Friday's state men
Wake Forest 78, UMBC 73: Devin Thomas had 21 points and 17 rebounds, Dinos Mitoglou added 19 points and 16 rebounds, and the host Demon Deacons relied on inside muscle to hold off the hot-shooting Retrievers in the season opener for both teams.
It was a nervous start to coach Danny Manning's second season with Wake Forest. UMBC, which went 4-26 last season, hit nine 3-pointers, led with under seven minutes left, and got within 72-71 on a steal and layup with 1:45 left by Rodney Elliott (John Carroll).
Tennessee State 86, Loyola Maryland 71: The visiting Tigers scored 21 of the game's final 27 points to rally past the Greyhounds in the season opener for both teams.