Makeda Nicholas had 12 points for Delaware (4-7) before leaving with an injury with 7:28 to play. The Blue Hens are 0-13 against the Terps.
"We belong on that same stage," Delaware coach Natasha Adair said. "Being on our home floor, we didn't look like we didn't belong. If you're intimated, you're already 15 points down before the ball even goes up, and this group is not."
Maryland had a 16-2 run to take a 24-10 lead with 7:29 left in the second quarter. The Blue Hens cut it to 27-21 with 2:56 remaining in the first half, but never got closer. They trailed 56-41 at the end of the third quarter.
Both teams struggled from the 3-point line, combining to miss 17 shots until Mikesell hit one with 2:06 left in the first half.
Maryland had 55 rebounds, and despite shooting only 36.8 percent, coach Brenda Frese liked her team's physical presence.