Forward Scott Eatherton scored 23 points and brought down 15 rebounds to lead the Huskies.
After an early 15-2 Northeastern run to make the score 20-13 in favor of the Huskies with just over eight minutes to play in the first half, Drexel coach Bruiser Flint called a timeout and began tearing into his starters, who stood in a circle around him.
But it didn't help.
A fast-break dunk from Northeastern guard David Walker stretched the Huskies advantage to 32-17. Two free throws from Dragons guard Frantz Massenat cut Northeastern's lead to 35-21 at halftime.
Eatherton said the Huskies' first-half run was the best the team had played all season.
"I think we kind of surprised ourselves," Eatherton said. "We thought it was going to be a lot closer. The difference was we were prepared for a run from them."
A 3-pointer from Huskies guard Demetrius Pollard gave Northeastern a 17-point lead, but two 3-pointers by Dragons guard Chris Fouch made the score 53-43 with 12 minutes to play. Huskies coach Bill Coen called a timeout to stop Drexel's momentum.
A layup from Dragons freshman Rodney Williams cut the deficit to nine points, but two free throws by Walker increased Northeastern's lead to 64-50. Walker hit an off-balance shot with five minutes to play to get Northeastern's lead back to 17.
Drexel showed signs of life once again when Fouch sank a fade-away 3-pointer from the right corner to cut the deficit to nine with under three minutes left. Northeastern turned the ball over on their next possession, but Drexel failed to capitalize. Eatherton sank a free throw with just over two minutes to play to put the lead back into double-digits and out of reach for Drexel.