Dylon Cormier (Cardinal Gibbons) scored 17 points and Julius Brooks added 13 for the Greyhounds (18-9, 10-5), who rebounded from Sunday's loss to Marist.
Jordan Heath had 15 points and eight rebounds, and Chris Hamhertz posted 14 points and 10 rebounds for the Golden Griffins (16-10, 9-6).
Loyola led 37-32 at the break after the Greyhounds shot 53.6 percent from the field while holding the Golden Griffins to 38.5 percent.
The teams traded leads early until Erik Etherly made a layup to give the Greyhounds a 22-21 advantage with 9:01 remaining, sparking a 10-1 run that put his team ahead 30-22.
The 44 points are the most by a Mount player since the school moved to NCAA Division I in 1988-89. Prescott entered the game averaging 9.2 points.
Mount St. Mary's jumped all over Bryant in the first half, building a 42-28 halftime lead.
Kelvin Parker had 19 points off the bench for the Mount, which has won two straight.
The Panthers (12-11, 4-7) led for most of the game.