Ravens run offense vs. Bills run defense: Over the past three seasons, the Ravens have rushed for an NFL-best 152.8 yards per game at home and a league-high 29 touchdowns. That's troubling news for the Bills, who have the NFL's worst run defense. Buffalo has surrendered an average of 182.4 yards on the ground and could be without starting nose tackle Kyle Williams (questionable, ankle). Defensive end Dwan Edwards, who played for the Ravens from 2004 to 2009, is the Bills' most active tackler at the point of attack. Ravens running back Ray Rice has totaled 221 yards rushing the past two weeks. Willis McGahee, who didn't play a snap last Sunday, is expected to get on the field as early as the third series.
Ravens pass offense vs. Bills pass defense: Buffalo has given up the fourth-most passing touchdowns (11) and has made the fewest interceptions in the NFL (one in 136 pass attempts). Quarterbacks have been efficient against the Bills, completing 68.4 percent of their passes. The availability of tight end Todd Heap, who expects to play with a neck injury, is important. In five games this season Buffalo has allowed tight ends to catch 32 passes for 407 yards and seven touchdowns. Joe Flacco has put up strong numbers the past four weeks, throwing six touchdowns and one interception (quarterback rating of 103.6). The Bills have lacked a consistent pass rush, producing six sacks (no one has more than one this season). Leodis McKelvin will start his fourth straight game in place of injured cornerback Terrence McGee (back), who has been ruled out.
Bills run offense vs. Ravens run defense: The Bills have two talented running backs in Fred Jackson (5.0-yard per carry) and rookie C.J. Spiller (4.2). In his last game, Jackson gained 73 yards on 12 carries. But the Bills have scored one rushing touchdown. The Ravens' run defense hasn't been as dominant as previous years yet is tied for 13th in the NFL. Patriots running back Danny Woodhead had 63 yards on 11 attempts (5.7-yard average) against the Ravens last Sunday. But the Bills have yet to commit to their ground game. They have the second-fewest rushing attempts in the NFL , and their running backs average 18 carries per game. Right tackle Cornell Green is out with a knee injury.
Bills pass offense vs. Ravens pass defense: This could mark the return of safety Ed Reed, who has been on the physically-unable-to-perform list after offseason hip surgery. His playmaking ability would be huge for a Ravens secondary that has two interceptions this season. Without Reed, the Ravens have put together the NFL's third-best pass defense (175 yards per game) and the top one on third downs (26.9 percent conversion rate). Bills quarterback Ryan Fitzpatrick has thrown for multiple touchdowns in his three starts this season. Wide receivers Steve Johnson, Lee Evans and Roscoe Parrish have touchdown catches over 30 yards. Haloti Ngata leads the Ravens with four sacks.
Special teams: Bills punter Brian Moorman was named to the NFL's all-decade team at the end of last season, but the Ravens' Sam Koch leads the NFL with 16 punts inside the 20-yard line. Ravens kicker Billy Cundiff tops the league with 14 touchbacks, which should negate Spiller (who has returned one kickoff for a touchdown this season). The Ravens are looking to jumpstart their return game (they rank 29th on punts and 22nd on kickoffs) against the Bills, whose coverage teams rank in the bottom half of the league. Prescott Burgess leads the Ravens with six special teams tackles.
Intangibles: The Bills are one of two winless teams in the NFL (Carolina is the other). They've allowed at least 34 points in their past four games. Buffalo has lost five of its past six road games. There's little concern of a letdown by the Ravens, who are 13-1 under coach John Harbaugh against teams with losing records. The Ravens have the NFL's third-best home record (60-22) since 2000. They've won five straight at M&T Bank Stadium. Plus, the crowd's emotions should be running high with the reunion of the 2000 Super Bowl team.
Prediction: The Ravens will take out their frustrations from last Sunday on the hapless Bills. And they'll do it with a score that the Super Bowl team will remember.
Ravens 34, Bills 7