The Mount had two 3-point attempts to stretch the lead into double figures, but the shots did not fall, and Wagner (10-8, 4-3) countered with an 8-0 run to even the score at 43 with 6:11 left in the game.
Kelvin Parker then hit a 3-pointer from the left corner to put the Mount ahead 46-43, and Raven Barber converted a hook shot with 3:53 left for a 48-44 advantage.
Wagner again responded, this time with six consecutive points for a 50-48 lead with 2:39 left. Latif Rivers started the run with a drive to the bucket, and Jonathon Williams added the next four points to give Wagner its first lead of the contest.
Prescott hit a jumper in the lane with 1:03 left to tie the game at 50. The Mount got the ball back when Orlando Parker missed the front end of a one-and-one with 49 seconds on the clock.
Wagner's Kenneth Ortiz, however, stepped in front of a pass, raced down court, and converted the go-ahead layup to give his team a 52-50 lead with 27.4 seconds remaining.
The Mount is back in action at 7 p.m. Saturday at Robert Morris.
Canisius 60, Loyola 46: The host Greyhounds led only once in a loss to the Golden Griffins on Field Trip Day at Reitz Arena.
Alyssa Sutherland led Loyola (6-12, 1-6 Metro Atlantic Athletic Conference) with 11 points and seven rebounds, and Katie Sheahin chipped in nine points and seven rebounds. Kara Marshall had a team-high four assists.
For Canisius (8-10, 5-2), Ashley Durham led with 21 points. The senior helped the Golden Griffins connect on 11 shots from behind the arc, a team high for the season.
Sutherland scored the first points for the Greyhounds, a 3-pointer from the top of the arc that gave Loyola their only lead.
The Golden Griffins led 28-17 at halftime.
The Greyhounds will return to action on Sunday when they face Iona in the second game of a doubleheader with the Loyola men. Tip-off is set for 2:30 p.m.
William & Mary 59, Towson 50: A strong defensive effort lifted the host Tribe (3-14, 1-5 Colonial Athletic Association) past the Tigers. Sophomore forward Markell Smith led Towson (6-11, 0-6) with a career-high 12 rebounds in the loss.
William & Mary opened the second half on a 17-6 run to take a 41-26 lead with 12:50 to play. Junior guard Tanisha McTiller finished with 19 points to lead the Tigers.