Second, most ophthalmic medications falter with formulation — developing a safe and effective method of getting the medication to the target organ, in this case, the lens. Getting a comfortable eye drop through the cornea and into the lens capsule is no small task as an almost impenetrable barrier surrounds the lens. This would require continued repetitive application of a medication for the entire life of a patient, even one who has not suffered symptoms. At best case scenario, many studies in both ophthalmology and other systemic diseases find that at least 20 percent of patients do not keep followup appointments, 40 percent of patients do not fill their initial prescription and 60 percent of patients do not persist with their therapies for even one year. Eye drops aren't easy to use. Our group's work has found that 17 percent of patients are reliant on others to instill a drop and less than 60 percent of patients were able to actually instill a single drop in their eyes successfully.