The same sources that bring news of potential calamities also report problems with scientific integrity and reproducibility. The question "Is science broken?" has been repeatedly raised. We answer emphatically that science is not broken. Spacecraft are exploring Ceres and Pluto, the Higgs boson was found, numerous genomes are decoded, AIDS is now a treatable disease, and new miracle drugs are on the horizon. Nevertheless, not all is well with the scientific enterprise. Public funding for science has been stagnant for many years, and this has taken a serious toll on the scientific culture and the rate of scientific progress. Science is under attack by forces waging war on some of its major successes. Vaccines, climate science, genetic engineering, evolutionary theory and even the moon landings have each been questioned. Increasing regulations hobble scientific research. Many scientists are poor communicators, increasing the challenge of fending off anti-science forces and convincing the public that more support is needed.