A budget that focuses on proactive ways in which we can reduce the incidence of disease, disorder and calamity holds more promise from a humanity and cost efficiency perspective than might be imagined. In all domains, problems can be avoided rather than addressed retroactively. The challenge, however, is that prevention requires up-front spending for a later pay-off, often in three to 10 years. But given that there is no overnight remedy for U.S. budget concerns, the promise of prevention justifies the investment. Moreover, costs can be offset to some degree by shifting money away from ineffective programs and soliciting additional private financing of prevention — such as "pay-for-success" bonds, a funding mechanism with bipartisan state-level support.