Drug addiction is an intergenerational disease, just as prevalent in the family tree as cancer or diabetes. In fact, studies found that animals exposed to prenatal stress tend to exhibit the same signs as seen in addiction and are more likely to self-medicate when given access. Addiction is a serious brain disease that targets the "opioid attachment-reward system, the dopamine-based incentive-motivation apparatus and the self-regulation areas of the prefrontal cortex." Essentially it hijacks the very parts of our brain responsible for goal-setting and motivation. It's a disease that is commonly comorbid with, or puts people at risk of, other mental and physical health concerns, like Post-Traumatic Stress Disorder (PTSD) or HIV, which means those suffering with addiction are also often combating other physical or mental health disease at the same time. PTSD prevalence alone was found to be five times higher in patients with Substance Use Disorders (SUDs). The comorbidity of the two diseases makes it difficult to overcome one or the other.