The evidence linking antidepressants and violence continues to mount. A 2010 study published in PloS One analyzed adverse drug event reports submitted to the FDA for a five-year period. Only drugs for which at least 200 adverse events were reported were included in the analysis — a total of 484 drugs in all, 11 of which were antidepressants. For each drug, the authors tabulated the incidence of violence case reports, which they defined as physical abuse, physical assault, homicidal ideation and homicide. For the majority of these 484 drugs, there were no violence case reports. For most of the rest, there were only one or two such reports. The 11 antidepressants stood out from the pack with a whopping 578 violence case reports, or 30 percent of the total. The proportion of violence cases reported for these drugs was eight times the average of all other drugs. Only the stop-smoking drug Chantix had a stronger violence signal.