The debate at WBFF-TV in Baltimore will be streamed live at 3 p.m. on FoxBaltimore.com and be shown at the same time on WJLA 24/7 in Washington.
WBFF anchor Jennifer Gilbert will be the moderator.
MyTV Baltimore will show the debate Sunday at 7 p.m. It will also be broadcast Oct. 13 on WBFF at 5 p.m.
Cardin is seeking his third term. Campbell, a Towson University lecturer and former U.S. Army chaplain, emerged from a crowded primary for the GOP nod. Simon’s campaign said it submitted more than 17,000 signatures to earn a spot on the November ballot.