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Ravens run offense vs. Colts run defense: During the past four games, Ray Rice has averaged 74.5 rushing yards and has scored five touchdowns. Teams have had success lately running on Indianapolis. The Colts have given up 100 rushing yards to three of their past four opponents. Strong safety Bob Sanders, one of the key defenders in stopping the run, is on injured reserve. Four of Indianapolis' top six tacklers are defensive backs. The Ravens are 5-0 when they run the ball more than 18 times a game. Edge: RAVENS

Ravens pass offense vs. Colts pass defense: Indianapolis has had to replace three starters in the secondary. Rookie cornerbacks Jerraud Powers and Jacob Lacey have taken over for the injured Kelvin Hayden and Marlin Jackson in the Colts' cover-2 scheme. Melvin Bullitt has stepped in for Sanders. The only remaining starter is free safety Antoine Bethea, who is questionable with a foot injury. Defensive ends Dwight Freeney and Robert Mathis have combined for 18 sacks, but Freeney is also questionable with a hip injury. The Ravens will likely be without tight end Todd Heap (chest), who would be replaced by L.J. Smith. Last season, Joe Flacco threw a season-worst three interceptions at Indianapolis. Edge: RAVENS

Colts run offense vs. Ravens run defense: Joseph Addai hasn't rushed for more than 64 yards in a game this season, but the Indianapolis running back has been a steady force. He has scored a touchdown in five of his past six games and has averaged 57.5 rushing yards in his past four games. Before being a nonfactor last season against the Ravens (two carries for 3 yards), Addai had 81 total yards and two touchdowns in Baltimore in 2007. The Ravens have limited teams to an average of 77 rushing yards in four home games. Defensive tackle Haloti Ngata (sprained ankle) is expected to return after missing two straight games. Edge: RAVENS

Colts pass offense vs. Ravens pass defense: This is the biggest disparity in the game. Quarterback Peyton Manning is 6-0 against the Ravens since 2002. In the past two meetings, he has thrown seven touchdown passes and averaged 11.5 yards per completion. This season, he has passed for 300 yards in eight of nine games. Wide receiver Reggie Wayne has 97.6 receiving yards per game and eight touchdowns. Tight end Dallas Clark has averaged 94.3 receiving yards in his past three games. The Ravens have allowed just one passing touchdown in their past three games, but in five games against former Pro Bowl quarterbacks, they have given up eight passing TDs and made three interceptions. Edge: COLTS

Special teams: One of the major story lines of the week was the kicking game. Matt Stover, who is 6-for-6 on field-goal tries this season, returns to Baltimore for the first time since the Ravens decided not to re-sign him this offseason. This also marks the first game for Billy Cundiff, who replaces the struggling Steve Hauschka as the Ravens' kicker. Cundiff was 6-for-6 on field goals for the Cleveland Browns earlier this season. Ravens rookie Lardarius Webb ranks fifth in the NFL in kickoff returns (28.3-yard average). The Colts' Chad Simpson (Morgan State) is 28th (22.4). Edge: EVEN

Intangibles: The Ravens, who haven't scored an offensive touchdown in the first half since Oct. 4, can't afford a slow start. There will likely be an emotional hangover for the Colts after their thrilling victory over New England a week ago. Indianapolis is banged up with four players out and six questionable. The Ravens, who have played three straight teams coming off byes, don't catch a break this week either; they are playing on short rest after playing Monday night in Cleveland. The Colts have won three straight in Baltimore, but the Ravens are 55-21 at M&T; Bank Stadium since 2000 (the NFL's third-best home record during that time). Edge: EVEN

Prediction: There has been only one constant in the Ravens' up-and-down season: The defense struggles against the top quarterbacks in the NFL. And there is no quarterback playing better than Manning this year. It's another emotional reunion that Baltimore fans will want to forget. COLTS, 30-20.

When the Ravens have the ball

Ravens offense

WR: 89 Clayton

LT: 71 Gaither

LG: 66 Grubbs

C: 77 Birk

RG: 65 Chester

RT: 74 Oher

TE: 86 Heap or 82 Smith

QB: 5 Flacco

FB: 33 L. McClain

RB: 27 Rice

WR: 85 Mason

Colts defense

DE: 98 Mathis

DT: 99 Johnson

DT: 90 Muir

DE: 93 Freeney

OLB: 50 Wheeler

MLB: 58 Brackett

OLB: 55 Sessions

LCB: 26 Hayden

SS: 33 Bullitt

FS: 41 Bethea

RCB: 25 Powers

When the Colts have the ball

Colts offense

WR: 87 Wayne

LT: 74 Johnson

LG: 65 Lilja

C: 63 Saturday

RG: 66 DeVan

RT: 71 Diem

TE: 44 Clark

WR: 85 Garcon

QB: 18 Manning

FB: 47 Robinson

RB: 29 Addai

Ravens defense

DT: 94 Bannan

NT: 97 Gregg

DE: 93 Edwards

OLB: 99 Kruger

ILB: 56 Gooden

ILB: 52 Lewis

OLB: 95 Johnson

LCB: 31 F. Washington

SS: 26 Landry

FS: 20 Reed

RCB: 24 Foxworth

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