With Bryant suffering from the flu, Lamar Odom scored a season-high 28 points - 15 in the third quarter - and Pau Gasol added 18 as the Los Angeles Lakers dominated the second half and handed Cleveland its first home loss this season, 101-91, yesterday.
Bryant was vomiting before the game and needed intravenous fluids at halftime, and Odom picked up the offensive slack, helped contain LeBron James on defense, and was the biggest factor in the Lakers' outscoring the Cavaliers 50-30 after halftime.
Odom, who added 17 rebounds, and the Lakers (41-9) outscored the Cavaliers 31-16 to turn a 10-point deficit into an 82-77 lead entering the fourth quarter.
James finished with 16 points on 5-for-20 shooting for Cleveland (39-10), which was 23-0 at Quicken Loans Arena and hadn't lost at home since Game 5 against the Washington Wizards in the first round of last season's playoffs.
The Lakers went 6-0 on a trip that also had stops in Minnesota, Memphis, New York, Toronto and Boston.
Bryant finished with 19 points for Los Angeles, which made just six turnovers.
Zydrunas Ilgauskas scored 22 to lead Cleveland, which shot 28 percent (11-for-39) in the second half. James finished with 12 assists and eight rebounds.
Roger Mason's three-pointer with 20.4 seconds left gave the Spurs (34-15) the lead for good.
Tim Duncan scored 23 points with 13 rebounds, Matt Bonner had 23 points - the second most in his career - and Manu Ginobili finished with 19 as a reserve to lead the Spurs to their ninth win in 11 games.
Kevin Garnett had 26 points and 12 rebounds, and Rajon Rondo had 16 assists for the Celtics (42-11).
Hornets 101, Timberwolves 97:: Sean Marks dunked with 7.8 seconds left to cap a career-high 18-point effort, and short-handed New Orleans (30-18) overcame the ejection of David West because of a flagrant foul to defeat visiting Minnesota (17-33).
Heat 96, Bobcats 92: : Dwyane Wade shook off flu-like symptoms to score 22 points, and Miami (27-23) held off visiting Charlotte (19-31).