Gerald Henderson added 19 points for the Blue Devils (11-1), who had no trouble winning their first game after an 11-day break. But Duke lost Smith midway through the first half to a left knee injury after he banged knees with another player, leaving the sophomore to spend most of the day sitting on the bench and wearing an ice bag. Smith said afterward it appears to be only a bone bruise.
"I think the initial prognosis is good," coach Mike Krzyzewski said.
The Blue Devils had too much depth and size against the Greyhounds (4-9), taking a double-digit lead in the first six minutes and never looking back.
Brian Rudolph had 13 points to lead Loyola, which shot 32 percent for the game.
NORTH CAROLINA STATE 88, TOWSON 68: : Tracy Smith entered the game looking to give his team a spark.
He ended up providing so much more.
Smith scored a career-high 31 points in 23 minutes off the bench to help the host Wolfpack defeat the Tigers. Smith made 10 of 15 shots from the field and all 11 of his free throws for N.C. State (9-2), which rallied from an 11-point deficit early in the first half.
"I was just very energized coming into the game," said Smith, whose previous career high was 14 points. "We started out slow, and I wanted to bring in positive energy. That's what I did."
Junior Hairston, Towson's leading scorer, rebounder and shot blocker, played just six minutes in the first half because of foul trouble.