Colts (3-3) @Titans (6-0)
TIME, TV: : 8:30, ESPN
LINE: : Titans by 4
FANTASY FACTOR: : The Colts' Peyton Manning has a 101.9 passer rating in 12 games vs. Tennessee with 20 TD passes and 10 interceptions. ... The Titans' defense is first in the AFC with 10 interceptions. ... Titans rookie Chris Johnson rushed for 168 yards last week.
THE BUZZ: : The Colts can ill afford another loss. ... The Titans are looking for their first 7-0 start and have won nine straight games going back to Dec. 16.