Colts (5-0) @ Jaguars (4-1) -- The Monday night grudge match could be a statement game for the Jaguars. They crushed the Colts in Jacksonville in December, rushing for 375 yards in a 44-17 rout.

Bears (2-4) @ Eagles (2-3) -- In a matchup of desperate, last-place teams, the Eagles can deliver a knockout punch to the Bears. Chicago's defense is in shambles, and its quarterback still turns the ball over too much.