The up-tempo play of the Terps (21-1) was too much for Lafayette, which won a school-record 19 games this season. The Leopards (19-2) were outshot 27-2.
Maryland will play No. 7 Old Dominion at 2 p.m. today at Artificial Turf Facility. Old Dominion, a 3-0 winner over Virginia yesterday, is the only team to beat Maryland this year, in the Terps' third game of the season, 5-3.
"The intensity level of our team was great today," said Maryland coach Missy Meharg. "We came out a little soft, but we grew into playing our normal high-paced, attacking style of hockey. I am really pleased with a lot of the goals we had today. They were really world-class scores."
Maryland jumped out to a 3-0 lead in the first half off two goals by Australian native Rachel Hiskins and one by Dina Rizzo.
Hiskins scored her first goal 6: 04 into the first half off a pass from Caroline Walker on a penalty corner. The Terps had 21 penalty corners. Lafayette had two.
"We gave up so many penalty corners that they were bound to score," said Lafayette coach Ann Gold.
Hiskins' second goal came on a penalty stroke with 2: 57 remaining in the first half.
Rizzo, who had two goals and one assist, scored her first goal with 8: 23 left in the first off a pass from Carla Tagliente, who scored the winning goal in double overtime to defeat Wake Forest, 2-1, in the Atlantic Coast Conference championship.
Maryland, with the nation's top-ranked scoring offense, added second-half goals by Keli Smith, Megan Kelly and Rizzo.
The six goals set a school record for goals in an NCAA tournament game. The previous high was four against Old Dominion in 1996.
Gold said she was satisfied with her team's season and its effort against the No. 1-ranked team in the country.
"[Maryland] just plays at a different level," Gold said.
The win was Maryland's 19th straight. It has outscored opponents 106-17, with seven shutouts during the streak.