The Cavaliers avenged a one-goal loss to Princeton in last year's NCAA championship game.
Virginia (3-0) jumped out to leads of 2-0 and 6-1 and was never threatened. The Tigers, national champions two of the past three years, dropped to 0-2 for the first time since 1987, a year before coach Bill Tierney's first season.
Princeton scored only one goal in the first 30 1/2 minutes.
"You have to give Virginia a lot of credit," Tierney said. "They did a great job on us defensively. They were able to take away our attack. You have to tip your hat to them."
The Cavaliers won 15 of 19 faceoffs, and had a 58-40 advantage in ground balls.
* Duke 10, Brown 7: Steve Finnell and Scott Harrison each had two goals and one assist as No. 8 Duke (3-1) edged No. 9 Brown (1-1) at Duke Lacrosse Stadium.
The Blue Devils jumped out to a 4-2 lead in the first quarter, HTC receiving scoring from four players. Finnell's goal eight seconds into the fourth pushed the lead to 9-7.
Duke junior goalkeeper Joe Kirmser recorded 15 saves. Brian McNally score three goals and David Evans added two goals and two assists for the Bears.
* Hofstra 15, Delaware 6: North Atlantic Conference newcomer and 14th-ranked Hofstra (1-0) handed No. 18 Delaware (1-2) its first conference loss ever in front of 1,311 at Hofstra Stadium. Chris Panos scored six goals and Kevin Jacobs dished out six assists as the Flying Dutchmen won their season opener.
After Delaware's Jason DeCarlo started the scoring one minute into the game, Hofstra reeled off four straight goals on the way to a 7-2 halftime lead and never looked back. The Fighting Blue Hens never got closer than four goals the rest of the way.
Delaware's two-time All-American Anthony DiMarzo scored two
goals to up his team-leading total to 12 while Chris Mach, Mark Cornes, Brad Glowaki each added goals for the Hens.
Brian Holland scored twice for Hofstra, which was outshot 40-37.
* Greensboro College 10, Washington College 9: Senior midfielder Brian Prescott scored four goals to power unranked Greensboro College (2-1) past No. 7 Washington College (0-3) at Kibler Field.
Greensboro was 1-for-14 in extra-man opportunities.
Shawn Callahan added two goals for the Pride. Greensboro goalie Ben Simmons made 12 saves.
The Shoremen opened a 2-0 lead just four minutes into the game, but the Pride came back to tie the game at 4. After Washington College pulled ahead to 6-4, Greensboro scored four times in seven minutes and never trailed again.
* Lynchburg 11, Western Maryland 7: Todd Perkins scored three goals and Lynchburg (3-2) limited Western Maryland (0-1) to single goals in the second and third quarters in a nonconference win at Loyola College's Curley Field.
The two teams split the game's first four goals, before Lynchburg ran off four straight. The Hornets led 5-2 at the end of the first quarter and 8-3 at the intermission.
Doug Dicconson and Brian Catney added two goals each for Lynchburg, which won back-to-back games for the first time this season.
Freshman Bo Schrott and Matt Hoppe each scored two goals for the Green Terror, which lost its seventh consecutive season opener.
* Elmira 11, Goucher 2: Junior midfielder Bill Kennedy scored three goals and two assists to lead visiting Elmira (1-0) over Goucher (1-1). Keith Guinto scored both Gophers' goals.
The Eagles jumped to an 8-0 lead and shut out Goucher for the first three quarters. The Gouchers were outshot 26-29.
* Gettysburg 14, Denison 5: Tim DeMore scored three goals to lead host No. 2 Gettysburg (2-0) to a victory over No. 4 Denison (1-1) in Division III game at Musselman Stadium. The Bullets scored nine of the final 10 goals.