Brandi Barnes and Erica Adams combined for 43 points to lead host Joppatowne (16-5) past Milford Mill, 61-50, in a Class 1A North semifinal.
Joppatowne, the defending regional champion and a 1A finalist last year, moves on to play at top-seeded Bohemia Manor tomorrow at 7 p.m.
The Mariners capitalized on some errant marksmanship by the Millers (13-8) for a 19-2 run that turned a 10-point deficit into a 50-43 lead with 3:49 left.
Adams had 12 of her points in the run and Barnes added 10.
Milford Mill went the last 5:19 of the third quarter and the first 6:30 of the fourth without a field goal.