Margaret Louise Dyer, a retired secretary in the Baltimore chapter office of the National Association for the Advancement of Colored People who had been active in Republican politics, died Sunday at Liberty Medical Center of complications from a paralyzing neurological disease.

Services for Mrs. Dyer, who was 77 and lived on Windsor Gardens Lane, were being held today at Faith Baptist Church, Bond Street and Ashland Avenue.

She retired nearly 10 years ago,having been secretary to two presidents of the local NAACP. She also worked for the Board of Supervisors of Elections and as a bookkeeper and auditor at the Archer Laundry.

In 1971, she was named Republican candidate for city comptroller by the local Republican State Central Committee at the request of Dr. Ross Z. Pierpont, who was running for mayor.

Mrs. Dyer, though unsuccessful, received more votes than did Dr. Pierpont in the general election.

A delegate to several Republican National Conventions, she also ran unsuccessfully in 1979 for a 2nd District seat on the City Council.

The former Margaret Louise Parker was a native of Baltimore and was educated at Dunbar and Douglass high schools.

She is survived by her husband, Martin Dyer; a daughter, Alma M. Lawson, and a son, Martin A. Dyer, both also of Baltimore; and five grandchildren.