Westbound Interstate 70 was closed for about five hours at Route 40 in Howard County after a fatal collision, according to Maryland State Police.
A box truck left the roadway on westbound I-70 and struck several trees. The driver was pronounced dead at the scene.
Because the accident involved a fatality, no other details on the crash are yet available.
The roadway was initially closed in both directions, but all lanes reopened at 1:04 p.m.