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A taste of success

Baltimore Sun

Anew treatment for malaria - which experts say kills a child in Africa every 30 seconds - might lie in the dregs of medicinal tea formerly produced by an Ellicott City woman's company.

Bad flavor might have undermined the lasting success of Diane Winn's first anti-malarial drug, a product called Phyto-Laria tea bags, which her company made until five years ago from the root of an African vine.

But now, the only thing Winn hopes to taste is success as a flavorless capsule form of the same drug soon heads for clinical testing and, if approved, a product launch by year's end.

Not bad for someone who graduated in 1959 with a degree in biology from tiny Cedar Crest College in Allentown, Pa., and who envisioned a long career behind a microscope or as a medical illustrator.

Winn said she didn't foresee her life of accomplishment and adventure in Ghana - befriending African leaders and villagers alike while striving to make important contributions to world health for nearly 50 years.

"I have been blessed to lead this amazing life, but the credit for these pharmaceutical advancements must be shared by many people," said Winn, 72, whose company hopes to have a reformulated drug on the market by the end of 2010.

A question of tasteThe problem with the acrid tea made from the root of the nibima plant was that some patients refused to sip their way through a complete course of it, said Winn, who has traveled to the West African country more than a hundred times over the decades.

"The tea bags were an easy way to administer the drug, and its bitterness was not something we thought would matter," she explained.

But like any medicine, failure to finish the prescribed amount can cause relapse or worse, she said, and so the search was on to find a better way to ensure patient compliance.

Phytica, a second company co-founded by Winn in 2006, has been working to resolve the taste issue under a public-private partnership with Noguchi Memorial Institute for Medical Research in Ghana. Researchers recently hit upon the idea of putting the effective plant extract into capsules to avoid the offensive flavor issue altogether.

Patients taking the Larax brand capsules will be rid of life-threatening parasites in about 3 1/2 days without adverse side effects, the same as when drinking the tea, Winn said. Even the highest fevers that accompany malaria will be reduced within 24 hours, she added.

"This has proved to be just an amazing drug," said Winn, who noted her company is also working on plant-based medicines for asthma and malnutrition, among others illnesses and conditions. Phytica's mission is "to advance global health while building sustainable businesses, employing Africans in farming, production and management, and raising Africa's standard of living," according to the company's Web site.

After clinical trials and approval by the Ghana Food and Drugs Board, Larax is slated to begin production in Ghana, which will create a need for local residents to grow nibima and to assist in manufacturing and sales, injecting millions of dollars into the country's economy, Winn said.

Africa incurs a $12 billion shortfall every year in its gross domestic product as a result of malaria, $760 million of that lost in Ghana alone, according to Phytica's Web site.

The war on malariaMalaria is transmitted through the bite of a female mosquito infected with the Plasmodium parasite and every bite can mean contracting another case of the potentially fatal disease, explained Winn.

Each year 350 million to 500 million cases of malaria occur worldwide and more than a million people die, most of them young African children living south of the Sahara, according to the Web site of the Centers for Disease Control and Prevention.

The World Health Organization reports that one in every five childhood deaths in Africa is because of the effects of the disease and that an average African child contracts between 1.6 and 5.4 episodes of malaria fever each year.

Winn acknowledged that research is being conducted on anti-malarial medicines by other companies, some of it centered on creating a vaccine and funded in part by the Bill and Melinda Gates Foundation.

"A vaccine will be the ultimate solution," Winn said. "But there will always be a market for a locally produced, anti-malarial drug."

A life-changing invitationWinn first traveled to Ghana in 1962 on a whim, agreeing to accompany a team of 20 fellow workers from the National Institutes of Health without even knowing where the country was. She was 25.

The medical research team had been sent by President John F. Kennedy at the request of then-Ghanaian President Kwame Nkrumah, she said, noting that Kennedy had just one year earlier sent Peace Corps volunteers to Ghana on that organization's first-ever assignment.

"When I first arrived I felt at home immediately - the people of Ghana are so outgoing and so friendly," said Winn. "Being there was the first time in my life that I felt comfortable in my own skin."

It was during this NIH mission that she met Dr. Oku Ampofo, a Ghanaian native and Western-trained physician who would make an indelible mark on her life.

"Dr. Ampofo wanted to treat his people but knew they couldn't pay him, so he began creating and selling wood sculptures to finance his medical practice," she said of her mentor. Examples of his work, carved from African cedar, ebony and an exotic wood called afzelia, prominently adorn her condominium.

One of Ampofo's sculptures, of a native woman mourning in the wake of Kennedy's assassination in 1964, sits in the Africa Room of the Kennedy Center in Washington, said Winn, who maintains a foundation in the physician's honor.

A talented artist herself, Winn has created spirit-filled portraits of many of her Ghanaian friends, imbuing an almost photographic reality to the drawings made with oil-based pastels. These also grace her home.

Ampofo was the guardian of the tightly kept secrets of traditional herbalists who lived in Ghana's most rural villages, the researcher said.

"It was phenomenal that they were willing to share their knowledge with him, since they usually only pass their secrets on to one of their children," she said.

Before he died in 1998 at age 90, the doctor implored Winn to commercialize the best of his plant medicines, she said.

"I believe I am supposed to be carrying on this work," she said. "This is what he asked me to do, and this is my mission in life."

Kwame Bawuah-Edusei, a medical doctor who recently was ambassador to Ghana for a three-year period, agreed with Winn's self-assessment.

"She has given her life to this, and I am quite comfortable with the scientific abilities of her team," he said, adding he has known Winn for about 10 years. "Her dedication and integrity are very rare and will see her through any challenges that may come her way."

Overcoming tragedy While Winn remains undeterred in her objectives, her will was profoundly tested three years ago when her husband died unexpectedly.

Dan Winn ardently supported his wife's work in Africa throughout their 13 years of marriage as co-founder of Phytica and by offering his expertise as a patent attorney and entrepreneur, she said.

But he died in 2006 after a fall down two flights of stairs in the parking garage of a Nairobi hotel where Diane Winn was scheduled to speak at a conference.

"That was the worst moment of my life," said Winn. Her family's support and her strong religious convictions helped pull her through that tragedy, she said. Likewise, a memorial service held by the Ghanaians helped steel her resolve.

"It has been very healing to jump back into this work and to commit myself to it in Dan's memory," she said, especially as Phytica appears to be near a breakthrough. Winn has also set up the Dan Winn Memorial Foundation.

"This medicine will help the people of Ghana, who are so well-educated and so gentle," she said. "The country is my second home."

Neighbors Is there a noteworthy person or event in your neighborhood? Contact Neighbors columnist Janene Holzberg at jholzberg76@msn.com or 410-461-4150.

Helping hands Thirty Sunday School students at the Fulton church where Diane Winn is a vice president are also making their mark in Ghana.

Winn brought word to St. Paul's Lutheran Church nearly 10 years ago about the Baptist Orphanage and School Complex (BASCO) in Trotor, a small village about 70 miles inland from the capital city of Accra, according to social outreach chairman Randy Arndt.

BASCO was established by Pastor Victor Ofori-Amoah in 1999 with four children who were abandoned after their parents were killed in a road accident. The orphanage is an independent, nonprofit and nondenominational organization that receives no direct support from the government, Arndt said. Today, BASCO supports 105 orphans and 292 students.

Diane and her late husband, Dan Winn, approached St. Paul's in 2000 to ask for $2,500 to replace the school's roof, a request that was approved by the church council. After that initial commitment by St. Paul's to provide assistance, Sunday School superintendent Debbie Marston decided to enlist the Youth Sunday School classes in grades one through five to help with other needs, Arndt said.

The students have raised nearly $15,000 over the years, including tuition money for nine children to attend high school, Arndt said. Members and church youths have donated computers, cameras, books, school supplies and board games, and have held numerous fundraisers to support BASCO.


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