McDaniel College junior Jacob Holechek, of Union Bridge, and senior Lamia Rhymee, of Westminster, both earned second place at the UMBC Undergraduate Research Symposium in the Chemical and Biological Sciences. The conference was held Oct. 22. Holechek, a chemistry and biochemistry major, collaborated with McDaniel College senior Evan Callahan on their oncology-based research titled "Design, Synthesis and Evaluations of Specific Inhibitors of Mono-(ADP-ribosyl) transferase, PARP-14." The students attempted to synthesize a selective chemical (small molecule) probe that will inhibit PARP-14 to find out what its function is in cancer progression. Rhymee, a chemistry major, collaborated with McDaniel College senior Kaitlynn-Marie Cendana on a paper titled "Characterizing Chromosome Rearrangements in Saccharomyces Yeast Using Single Molecule Long-Read Sequencing." The students tested the possibility of using a new single-molecule sequencing method to characterize genomic rearrangements in yeast.



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