Long before the construction of Md. 30, the route was a major thoroughfare for American Indians.
According to the book "Two Centuries of Grace and Growth In Manchester 1760-1960, Third Edition Update to 1984," by Harvey G. Schlichter, the town was constructed at the intersection of two major trails, one that ran between the Potomac and Susquehanna rivers and another that ran from the Conewago River to the Patapsco River, roughly connecting Hanover, then called Conewago, to Baltimore.
The region was home to the Susquehannock tribe until about 1750, the book says.
In time, the north-south trail was converted into a roadway by Robert Owings, the state's deputy surveyor at the time. Owings' roadway extended from Joseph Ellege's home in Woodensburg to Manchester and Hampstead, as well as Conewago.
That road, now Md. 30, was referred to as the Conewago Road before getting the name Hanover Pike during colonial times, according to the book.