Baltimore police are looking for 7-month-old Ki'Yauhn Birch and 16-year-old Jonae Boozer, who have not been seen since Friday evening.
Birch was left in Boozer's care, police said, and neither of the child's parents have been able to locate them since.
They were last seen in the 1100 block of Lyndhurst St., police said. Authorities believe Boozer may be in the Prince George's or Montgomery County area.
Boozer is a black female, about 155 pounds and 5-feet, 4-inches tall, according to police, has a blond mohawk hairstyle and piercings in her lips, nose and eyebrow. She was last seen wearing a purple leopard print outfit, said police.
Anyone with information on their location is urged to call detectives at 410-396-2100.