The man driving was transported to Maryland Shock Trauma Center with serious injuries that did not appear to be life-threatening, Rogers-Feher said.
"He was conscious, he was breathing, he was talking," she said.
The intersection does not have barrier arms that descend when a train is passing through, only signs warning of trains, Rogers-Feher said. Schaefer's Lane was closed for hours because of the accident.
No one on the train was injured, and Baltimore County police were investigating the incident, she said.
About 12:45 p.m., a single wheel on a car of a another CSX train briefly derailed in Woodstock in Howard County, causing the train to block a local intersection for hours but causing no injuries, officials said.
The train, which had four locomotives and 80 freight cars, was traveling east from Cumberland to Baltimore through the railway's intersection with the 1400 block of Woodstock Road when one of its cars "momentarily came off the tracks, only to return shortly thereafter," officials said.
The train was not carrying hazardous materials, but about 40 residents of nearby homes and patrons of the Woodstock Inn were evacuated as a precaution, officials said.
Sullivan said an investigation into why the derailment has begun. Sullivan did not know what sort of cargo the train was carrying.
Police and fire officials from Howard, Baltimore and Carroll counties responded to the scene.