Over the last decades treatment has steadily improved, despite this being the most aggressive of brain cancer malignancies. However, progress has been very slow and incremental. Improvements in surgery, radiation and the introduction of one type of chemotherapy have moved what used to be a 3 to 6 month survival to 15 to 20 months at the best centers, with the best trained surgeons, oncologists and radiation therapists. One of the main reasons that treatments have not improved more is the location of the cancer cells, intertwined with the most vital areas in the human body. Although the surgeon can remove the bulk and majority of the tumor in most cases, depending on the location within the brain, individual glioblastoma cells diffuse or migrate throughout the brain long before the tumor is diagnosed. These cells cannot be removed, and the chemotherapies we have so far don't reach the brain in sufficient concentrations to be effective, and/or are too toxic to be useful. So far there is just one oral drug that is proven to improve survival, temozolomide, but it is just months of improved survival benefit.