Here’s a look at the largest spreads in our database, which tracks historical NFL betting information since the start of the 2003 season:
Jacksonville Jaguars at Denver Broncos (-27) on Oct. 13, 2013
Philadelphia Eagles at New England Patriots (-24) on Nov. 25, 2017
Miami Dolphins at Dallas Cowboys (-22) on Sept. 22, 2019
Miami Dolphins at New England Patriots (-22) on Dec. 23, 2017
The Cowboys were the only favorites of the four to cover the spread, beating the Dolphins 31-6 last season.
It’s important to note that the 21-point Jets vs. Chiefs spread is simply a lookahead line, meaning there’s plenty of time for that number to move/adjust while the four games cited above are true closing lines.