Crystal Cruises will offer a one-time, 11-day cruise from Baltimore to Miami aboard the Crystal Symphony in November.
It's the third year in a row the luxury cruise liner has sailed from Baltimore as it travels around the world.
The 922-passenger ship emerged from a $20 million redesign in a German shipyard in September that renovated lounges, the casino, spas and the fitness center, and added hypoallergenic staterooms.
The cruise from Baltimore, dubbed "Colonial Coast & Beyond," will call in Charleston and Jacksonville, before continuing to the Caribbean with stops in Grand Turk, Curacao and Aruba. All-inclusive fares start at $4,290 per person, according to Crystal Cruises' website.
In 2014, nearly 200,000 passengers sailed on 89 cruises from the port of Baltimore, sustaining about 500 jobs in the state. The Port of Baltimore ranks fifth for cruise passengers among East Coast cruise ports.