Felix Pie became the second Oriole to hurt himself on the basepaths in consecutive innings.
His injury is being classified as a left quad strain and he also will be re-evaluated Saturday.
Pie grounded out to first to end the top of the sixth inning, and when he turned back to the Orioles dugout, he began limping noticeably. He was met by assistant athletic trainer Brian Ebel at home plate, before Pie walked slowly to the dugout.
He was replaced in the bottom of the sixth by Jake Fox in left.
In the Orioles' fifth, Matt Wieters left the game after he fell running from second to third.
The official word is that Wieters has a right hamstring strain and will be re-evaluated tomorrow. It's the same hamstring that was "tight" this week and forced him to miss Thursday's game.