All four full-season affiliates in the Orioles' minor league system lost Wednesday.
The Triple-A Norfolk Tides failed to score against the Syracuse Chiefs, and the Double-A Bowie Baysox were also kept off the scoreboard in a loss to the Richmond Flying Squirrels.
The Single-A Frederick Keys fell to the Salem Red Sox, and the Single-A Delmarva Shorebirds dropped a game to the Kannapolis Intimidators.
Score: Syracuse Chiefs 4, Norfolk Tides 0 (Box score)
Recap: All eyes were on Syracuse starting pitcher Stephen Strasburg (2-0) and he didn't disappoint.
Strasburg tossed six no-hit innings as the Chiefs cruised past the Tides, 4-0. The 21-year-old right-hander struck out seven batters and issued one walk, throwing 55 of his 80 pitches for strikes.
Norfolk starting pitcher Troy Patton (2-4) gave up four runs, six hits and three walks in five innings. The 24-year-old left-hander had two strikeouts.
Tides right fielder Blake Davis hit a double and third baseman Josh Bell picked up the team's only other hit.Bowie Baysox (AA)
Score: Richmond Flying Squirrels 5, Bowie Baysox 0 (Box score)
Recap: Starting pitcher Ryohei Tanaka (2-4) gave up five runs and nine hits in 5 2/3 innings as the Baysox were blanked, 5-0, by Richmond at Prince George's Stadium.
Bowie left fielder Tyler Henson was 2-for-5 with a double, and second baseman Ryan Adams extended his hitting streak to 10 games with two hits and a walk.
Third baseman Brandon Waring was 0-for-1 with four walks for Bowie.
Score: Salem Red Sox 6, Frederick Keys 4 (Box score)
Recap: First baseman Joe Mahoney was 2-for-4 in the Keys' 6-4 loss to Salem.
Frederick second baseman L.J. Hoes and right fielder Ronnie Welty each contributed a single and an RBI, while center fielder Xavier Avery and catcher Luis Bernardo each added an RBI.
Keys starting pitcher Nathan Nery (2-3) allowed five runs and seven hits in 4 2/3 innings. The 24-year-old left-hander walked three batters and collected four strikeouts.
Shortstop Greg Miclat scored twice for Frederick.
Score: Kannapolis Intimidators 8, Delmarva Shorebirds 3 (Box score)
Recap: Third baseman Tyler Kelly was 3-for-5 with an RBI, but the Shorebirds were beaten, 8-3, on the road against Kannapolis.
Delmarva left fielder Michael Planeta added three hits and a run scored, while catcher Michael Ohlman and shortstop Garabez Rosa each added an RBI.
Shorebirds starting pitcher Jake Cowan (3-1) suffered his first loss of the season after allowing six runs and nine hits in five innings. The 21-year-old right-hander collected six strikeouts and gave up two home runs.