In the eighth, Kevin Millwood got two quick outs before third baseman Miguel Tejada booted a grounder. The next batter, Jose Bautista, hit a hanging curve into the left-field seats and the Orioles trailed 3-2.
The next batter, Alex Gonzalez, also homered -- his second of the game and fourth of the young season -- and the Orioles trail 4-2.
It wiped out what had been a wonderful performance by Millwood, who walked off the mound to a nice round of applause from the crowd of 22,499.
Matt Albers is into pitch, and the Orioles will need a comeback to avoid the sweep. They'll have to do better with men in scoring position. They are 1-for-8 through seven innings in that category.