McDonald, who was selected in the first round of the 1997 MLB draft, hit a two-run home run as a pinch hitter in the bottom of the eighth inning against Rangers left-hander Darren Oliver to tie the score at 6.
Still, McDonald wasn't finished for the night. With the bases loaded and two outs in the bottom of the ninth, he smacked a single off the Green Monster -- which was close to a walk-off grand slam -- to allow the game-winning run to score.
The 31-year-old outfielder was recalled earlier in the day when the Red Sox placed outfielders Jacoby Ellsbury and Mike Cameron on the 15-day disabled list.
After tomorrow's day off, the Orioles head to Boston for a three-game series. They'll also host the Red Sox next week at Camden Yards.
With Ellsbury out of action for at least the next week with a chest bruise and Cameron facing extended time on the DL because of a sports hernia, McDonald could get plenty of time to prove himself to the organization that drafted him.