The Triple-A Norfolk Tides look to snap a two-game losing streak when they face the Charlotte Knights at Harbor Park, while the Double-A Bowie Baysox hope to remain hot against the Harrisburg Senators at Prince George's Stadium.
The Single-A Frederick Keys play their home opener against the Myrtle Beach Pelicans at Harry Grove Stadium, and the Single-A Delmarva Shorebirds take on the Greensboro Grasshoppers.
Charlotte Knights (7:15 p.m.)
Norfolk: Chris Tillman (0-1, 4.50 ERA)
Charlotte: Lucas Harrell (0-0, 9.53 ERA)Bowie Baysox (AA)
Harrisburg Senators (7:05 p.m.)
Bowie: Zach Britton (0-0, 4.15 ERA)
Harrisburg: Jeff Mandel (0-1, 8.31 ERA)
Myrtle Beach Pelicans (7 p.m.)
Frederick: Oliver Drake (0-0, 0.00 ERA)
Myrtle Beach: Jose Ortegano (9-7, 3.22 ERA with two minor league teams in 2009)
at Greensboro Grasshoppers (7 p.m.)
Delmarva: Ryan Berry (0-0, 1.80 ERA)
Greensboro: Matthew Montgomery (0-1, 0.00 ERA)