The Triple-A Norfolk Tides fell to the Charlotte Knights, while the Double-A Bowie Baysox edged the Harrisburg Senators.
The Single-A Frederick Keys swept the Kinston Indians, and the Single-A Delmarva Shorebirds lost to the West Virginia Power.
The short-season Aberdeen IronBirds needed plenty of extra work to beat the Brooklyn Cyclones.
The rookie-level Bluefield Orioles dropped a close game to the Danville Braves, and the rookie-level GCL Orioles blanked the GCL Twins.
Score: Charlotte Knights 7, Norfolk Tides 1 (Box score)
Recap: Starting pitcher Troy Patton (1-3) allowed five runs and 10 hits in four innings, and the Tides suffered a 7-1 loss to Charlotte. Since joining Norfolk last month, the 23-year-old left-hander has a 5.47 ERA in five starts.
Tides center fielder Justin Christian was 2-for-4 with a double, and second baseman Justin Turner added a double and a run scored. The two players combined for Norfolk's only three hits in the game.
Norfolk shortstop Blake Davis was 0-for-3 with a fielding error.
Relief pitcher Josh Perrault tossed 1 2/3 scoreless innings for the Tides.Bowie Baysox (AA)
Score: Bowie Baysox 3, Harrisburg Senators 2 (Box score)
Recap: Second baseman Miguel Abreu hit a solo home run with two outs in the bottom of the eighth inning to lift the Baysox to a 3-2 victory over Harrisburg at Prince George's Stadium.
Bowie right fielder Ambiorix Concepcion was 2-for-4 with a two-run home run, while shortstop Brandon Pinckney and catcher Adam Donachie each added a double.
Baysox starting pitcher Ryohei Tanaka gave up one run and one hit in five innings, but he didn't factor in the decision. The 26-year-old right-hander struck out five batters and issued four walks.
Relief pitcher Luis Lebron (1-0) suffered a blown save for the Baysox, but he earned the win after allowing one run, one hit and two walks in one inning.
Bowie relief pitcher Ryan Ouellette tossed a scoreless ninth for his second save of the season.
Score: Frederick Keys 4, Kinston Indians 2 (Box score)
Recap: First baseman Brandon Waring and catcher Caleb Joseph each hit a solo home run in the Keys' 4-2 victory over Kinston. It was Waring's 15th home run of the season, while Joseph now has seven.
Frederick right fielder Robbie Widlansky was 1-for-3 with an RBI and a stolen base, and shortstop Pedro Florimon Jr. also picked up an RBI with a sacrifice fly.
Keys starting pitcher Sean Gleason (1-3) allowed two runs (one earned) and three hits in seven innings. The 23-year-old right-hander collected six strikeouts and walked one batter.
Relief pitcher Pat Egan tossed two scoreless innings to pick up his second save since joining the Keys last month.
Score: West Virginia Power 5, Delmarva Shorebirds 3 (Box score)
Recap: Designated hitter Elvin Polanco was one of five Shorebirds players with a multi-hit game, but they lost, 5-3, to West Virginia. The 22-year-old switch-hitter was 2-for-4 with a double.
Delmarva center fielder Kyle Hudson was 2-for-5 with a run scored, and first baseman Joe Mahoney collected two hits and a stolen base.
Second baseman Buck Britton added two hits and a run scored, while catcher Luis Bernardo picked up a single and a double.
Shorebirds starting pitcher Oliver Drake (4-6) gave up four runs and seven hits in 4 2/3 innings. The 22-year-old right-hander struck out five batters and issued three walks.
Score: Aberdeen IronBirds 1, Brooklyn Cyclones 0, 16 innings (Box score)
Recap: Outfielder Arthur Bonevacia's RBI single in the top of the 16th inning lifted the IronBirds to a 1-0 victory over Brooklyn. It was Aberdeen's second consecutive win in extra innings against the Cyclones.
IronBirds starting pitcher Kenny Moreland tossed seven scoreless innings, but he was long gone before the game was decided. The 23-year-old right-hander struck out six batters and allowed three hits. Moreland has a 0.36 ERA in four starts for Aberdeen.
Aberdeen relief pitcher Jake Smith (1-0) only gave up one hit in six innings to collect the win. The 23-year-old left-hander collected six strikeouts and walked one batter.
Relief pitcher Stephen Procner picked up his second save of the season for Aberdeen.
Score: Danville Braves 2, Bluefield Orioles 0 (Box score)
Recap: The Orioles managed only four singles in a 2-0 loss to Danville.
Bluefield starting pitcher Jesse Beal (2-2) gave up two runs and seven hits in 7 1/3 innings, but he was the tough-luck loser. The 18-year-old right-hander struck out four batters and didn't issue any walks.
Orioles relief pitcher Sam Taveras recorded the final two outs.
Score: GCL Orioles 5, GCL Twins 0 (Box score)
Recap: Center fielder Edwin Cintron was 3-for-5 with an RBI, a run scored and two stolen bases in the Orioles' 5-0 victory over the Twins.
Orioles second baseman Bo Ford collected two doubles, an RBI and two runs scored, while catcher Xavier Lopez was 1-for-3 with two RBIs.
Starting pitcher Zachary Petersime (2-0) tossed six scoreless innings for the Orioles. The 20-year-old right-hander allowed three hits, walked four batters and collected two strikeouts.
Orioles reliever David Walters pitched the final three innings to pick up his first save of the season.