The Triple-A Norfolk Tides beat the Charlotte Knights, while the Double-A Bowie Baysox fell to the Harrisburg Senators.
The Single-A Frederick Keys topped the Kinston Indians, but the Single-A Delmarva Shorebirds were beaten by the West Virginia Power.
The short-season Single-A Aberdeen IronBirds edged the Brooklyn Cyclones.
The rookie-level Bluefield Orioles used some late-inning heroics to knock off the Danville Braves, while the rookie-level GCL Orioles lost to the GCL Reds.
Earlier today, the Orioles announced their organizational players of the month for June. Bowie's Brian Matusz was selected as the top pitcher in the Orioles' minor league system, and the Shorebirds' Ronnie Welty was picked as the top hitter.
Before tonight's game, the Shorebirds placed second baseman L.J. Hoes on the temporary inactive list. A corresponding move is expected on Thursday.
Score: Norfolk Tides 5, Charlotte Knights 1 (Box score)
Recap: Center fielder Joey Gathright was 4-for-5 with a double and two RBIs in the Tides' 5-1 victory over Charlotte.
Norfolk starting pitcher Chris Tillman (7-5) tossed six scoreless innings. The 21-year-old right-hander gave up six hits and collected six strikeouts. He threw 61 of his 94 pitches for strikes.
Tides right fielder Jeff Fiorentino also picked up four hits, and catcher Robby Hammock added a double and two runs scored.
Shortstop Blake Davis was 1-for-3 with a stolen base and an RBI for Norfolk.Bowie Baysox (AA)
Score: Harrisburg Senators 7, Bowie Baysox 4 (Box score)
Recap: Orioles shortstop Cesar Izturis was 0-for-3 in his second injury rehabilitation start as the Baysox lost, 7-4, to Harrisburg at Prince George's Stadium.
Bowie second baseman Miguel Abreu was 2-for-4 with an RBI and a run scored, and right fielder Ambiorix Concepcion added a double, an RBI and a run scored.
Baysox starting pitcher Tim Bascom (2-2) allowed three runs and seven hits in six innings. The 24-year-old right-hander struck out four batters and didn't walk anyone.
Relief pitcher Zach Clark tossed two scoreless innings for the Baysox in his first appearance since rejoining the team from the disabled list.
Harrisburg third baseman Joel Guzman was 5-for-5 with three RBIs.
Score: Frederick Keys 6, Kinston Indians 2 (Box score)
Recap: First baseman Robbie Widlansky collected four hits and an RBI in the Keys' 6-2 win over Kinston. The 24-year-old utility player is batting .388 with two home runs and 23 RBIs in 31 games for Frederick since being added to the roster.
Frederick shortstop Pedro Florimon Jr. was 3-for-5 with two RBIs and a stolen base, while center fielder Matt Angle added two RBIs.
Third baseman Brandon Waring, catcher Caleb Joseph and left fielder Tyler Henson each picked up two hits for the Keys.
Starting pitcher Nathan Nery (3-3) gave up two runs and seven hits in five innings for Frederick, and relief pitcher Eddie Gamboa retired all nine batters he faced.
Score: West Virginia Power 7, Delmarva Shorebirds 3 (Box score)
Recap: Shortstop Greg Miclat was 2-for-4 with an RBI, a stolen base and a run scored, but the Shorebirds dropped a 7-3 decision against West Virginia.
Welty added an RBI, while Delmarva left fielder Kyle Hudson and catcher Luis Bernardo each scored a run.
Shorebirds starting pitcher Ryan O'Shea (5-5) gave up five runs and six hits in 4 2/3 innings. The 23-year-old right-hander struck out four batters and issued two walks.
Relief pitcher Cliff Flagello retired all seven batters he faced for Delmarva.
Score: Aberdeen IronBirds 5, Brooklyn Cyclones 4, 12 innings (Box score)
Recap: The IronBirds scored a run in the top of the 12th inning to snap Brooklyn's 10-game winning streak with a 5-4 victory. It was also the Cyclones' first loss at home in 2009.
Aberdeen third baseman Levi Carolus collected three more hits tonight, including the game-winning RBI single in the 12th. In his past four games, the 21-year-old infielder is hitting .611 (11-for-18) with two doubles and three RBIs.
IronBirds second baseman Buck Britton was 3-for-5 with a double, two RBIs and a run scored, while center fielder Richard D'Oleo and right fielder Jason Rook each added two hits.
Relief pitcher Jose Barajas (1-1) picked up the win for Aberdeen after retiring all six batters he faced, and James Brandhorst tossed a scoreless inning for his first save of the season.
First baseman Tyler Townsend was 0-for-6 with two strikeouts for the IronBirds tonight. So far this season, the Orioles' third-round selection in this year's MLB draft is batting .152 with 15 strikeouts in nine games.
Aberdeen starting pitcher Tyler Sexton allowed three runs (two earned) and eight hits in six innings.
Score: Bluefield Orioles 4, Danville Braves 3, 12 innings (Box score)
Recap: Second baseman Gary Helmick hit a solo home run with two outs in the bottom of the 12th inning to send the Orioles to a 4-3 walkoff victory over Danville.
Bluefield right fielder Luis Ramirez was 3-for-5 with two RBIs, and shortstop Javier Santana added two hits and a run scored.
Orioles starting pitcher Justin Moore gave up two runs (one earned) and six hits in six innings, but he didn't factor in the decision. The 19-year-old right-hander struck out three batters and didn't walk anyone.
Despite suffering a blown save, Bluefield relief pitcher Josh Dowdy (1-0) tossed four innings to earn his first professional victory. The Orioles' 38th-round selection in this year's MLB draft allowed one run and four hits.
Score: GCL Reds 6, GCL Orioles 1 (Box score)
Recap: Second baseman Dennis Perez collected a double and two walks in the Orioles' 6-1 loss to the Reds.
Orioles starting pitcher Jario De La Cruz (0-1) gave up three runs and five hits in six innings. The 21-year-old right-hander collected six strikeouts and walked two batters.
Relief pitcher Jason Hallerman issued three walks without recording an out for the Orioles. In four appearances this season, the 21-year-old right-hander has allowed four runs and 10 walks in 1 2/3 innings. However, he hasn't given up any hits.